ICI 89406

Research use only, not for human use.

ICI 89406 is a β-adrenergic antagonist.

ICI 89406 is a β-adrenergic antagonist.

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Animal Model:Rats.Dosage:0.6, 5 or 50 mg/kg.Administration:Orally (5 or 50 mg/kg), i.p. (5 mg/kg), i.v. 0.6 (0.6 mg/kg) (Pharmacokinetic Analysis).Result:Following oral administration, the dose of 5 mg/kg urinary and faecal excretion accounted for 5.8 + 0.7% and 96.4 + 2.1%. The dose of 50 mg/kg urinary and faecal excretion accounted for 14.0 + 4.0% and 78.4 + 2.4%. The proportions of unchanged drug and metabolites in urine were independent of the dose. The unchanged drug accounted for 81.6% of the faecal components after a dose of 5 mg/kg but this was reduced to 47.8%.

1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea

Angiogenesis

Adrenergic Receptor

CaSR

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——

53671-71-9

354.41

C19H22N4O3

>98% (HPLC)

——

O[C@@H](CNCCNC(=O)Nc1ccccc1)COc1ccccc1C#N

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(-20℃)

With Ice Pack

≥ 2 years